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Current Topics in Membranes, Volume 47: Amiloride-Sensitive Sodium Channels, Physiology and Functional Diversity

Current Topics in Membranes, Volume 47: Amiloride-Sensitive Sodium Channels, Physiology and Functional Diversity

Dale J. Benos
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Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.
Key Features
* Analysis of structure-function relationships of epithelial sodium channels
* Immunolocalization of epithelial sodium channels
* Hormonal regulation of sodium channels
* Sodium channels in lymphocytes, kidney, and lung
* Mechanosensitivity of amiloride-sensitive sodium channels
* Sodium channels and disease
Language
English
Pages
384
Format
Paperback
Publisher
Academic Press
Release
October 29, 1999
ISBN
0120890305
ISBN 13
9780120890309

Current Topics in Membranes, Volume 47: Amiloride-Sensitive Sodium Channels, Physiology and Functional Diversity

Dale J. Benos
0/5 ( ratings)
Read Download
Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.
Key Features
* Analysis of structure-function relationships of epithelial sodium channels
* Immunolocalization of epithelial sodium channels
* Hormonal regulation of sodium channels
* Sodium channels in lymphocytes, kidney, and lung
* Mechanosensitivity of amiloride-sensitive sodium channels
* Sodium channels and disease
Language
English
Pages
384
Format
Paperback
Publisher
Academic Press
Release
October 29, 1999
ISBN
0120890305
ISBN 13
9780120890309

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