The first book on this emerging hot topic is an introductory guide to the realm of unfolded or non-folded proteins. Based on their decades of practical experience, the authors explain the biochemical and biophysical reasons for disorder in proteins, survey analytical techniques to detect and model such disorder, and discuss the importance of disorder for protein function and malfunction. They conclude by introducing a number of well-documented examples of disordered proteins, including some that play a central role in such diseases as cancer and neural degeneration.
By starting with basic considerations and slowly working up to more complex questions, this didactic book can be profitably read by everyone -- from student to professional researcher.
Language
English
Pages
350
Format
Hardcover
Publisher
Wiley-VCH Verlag GmbH
Release
September 01, 2009
ISBN
3527322000
ISBN 13
9783527322008
Intrinsic Disorder in Proteins: The Principles and Practice of Unfoldomics
The first book on this emerging hot topic is an introductory guide to the realm of unfolded or non-folded proteins. Based on their decades of practical experience, the authors explain the biochemical and biophysical reasons for disorder in proteins, survey analytical techniques to detect and model such disorder, and discuss the importance of disorder for protein function and malfunction. They conclude by introducing a number of well-documented examples of disordered proteins, including some that play a central role in such diseases as cancer and neural degeneration.
By starting with basic considerations and slowly working up to more complex questions, this didactic book can be profitably read by everyone -- from student to professional researcher.